Related Experiment Video
Updated: May 12, 2026
08:52
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Pertussis re-emergence in the post-vaccination era
Elena Chiappini1, Alessia Stival, Luisa Galli
1Anna Meyer University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.
BMC Infectious Diseases
|March 28, 2013
Summary
Pertussis (whooping cough) is resurging, shifting to older age groups. Combining vaccination strategies, like cocooning and adolescent/adult immunization, offers the most effective control for pertussis (whooping cough).
Area of Science:
- Immunology
- Public Health
- Vaccinology
Background:
- Pertussis (whooping cough) incidence is increasing in Western countries.
- Cases are shifting from children to adolescents, adults, and infants, with sustained infant mortality.
- Current vaccination strategies require review to improve pertussis control.
Purpose of the Study:
- To review and discuss potential vaccination strategies for improved pertussis control.
- To analyze the effectiveness and cost-effectiveness of various pertussis immunization programs.
Main Methods:
- Searches of PubMed and CDC websites (US and European) were conducted.
- Data were collected between January 1, 2002, and March 1, 2013.
- Retrieved vaccination strategies were analyzed for their impact on pertussis control.
Main Results:
- Cocooning and maternal vaccination strategies show cost-effectiveness.
- Adolescent and adult vaccination is cost-effective but may not reduce infant pertussis incidence.
- Logistical and economic challenges exist for widespread adult vaccination.
Conclusions:
- A combined approach, including cocooning and adolescent/adult vaccination, is the most reasonable preventive measure.
- Developing new, highly immunogenic pertussis vaccines remains a key objective.
- Improving pertussis control requires a multi-faceted vaccination strategy.
More Related Videos
Related Concept Videos
01:51Vaccinations
Overview
01:28Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
01:28Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
01:23Immunological Memory
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
01:21Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...