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[Thyroid clinical dysfunction in patients chronically treated with amiodarone]
R V García1, M Gómez Sobreira, J Batista
1Sección de Endocrinología, Hospital Xeral de Vigo.
Revista Espanola De Cardiologia
|April 1, 1990
Summary
This study found that 3% of patients on chronic amiodarone treatment developed thyroid dysfunction, with equal rates of hyperthyroidism and hypothyroidism. Clinical indexes effectively monitored thyroid function in these cardiac arrhythmia patients.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Context:
- Amiodarone is a widely used antiarrhythmic drug.
- Chronic amiodarone use is associated with various adverse effects, including thyroid dysfunction.
- Monitoring thyroid function is crucial in patients receiving long-term amiodarone therapy.
Purpose:
- To determine the incidence of new-onset thyroid dysfunction in patients chronically treated with amiodarone for cardiac arrhythmias.
- To evaluate the utility of clinical indexes in monitoring thyroid function during amiodarone therapy.
- To assess the prevalence of amiodarone-induced hyperthyroidism and hypothyroidism.
Summary:
- A prospective study followed 132 patients without prior thyroid issues on chronic amiodarone for cardiac arrhythmias.
- Thyroid status was monitored using clinical indexes and biochemical tests over a mean follow-up of 20 months.
- The incidence of new thyroid dysfunction was 3%, with equal rates of hyperthyroidism and hypothyroidism, consistent with adequate iodine intake.
Impact:
- Clinical indexes are a useful and economical method for monitoring thyroid function in amiodarone-treated patients.
- Early detection of thyroid dysfunction can prevent serious complications.
- Findings support routine thyroid function monitoring in patients on long-term amiodarone therapy.