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[Thyroid clinical dysfunction in patients chronically treated with amiodarone].

R V García1, M Gómez Sobreira, J Batista

  • 1Sección de Endocrinología, Hospital Xeral de Vigo.

Revista Espanola De Cardiologia
|April 1, 1990
PubMed
Summary
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This study found that 3% of patients on chronic amiodarone treatment developed thyroid dysfunction, with equal rates of hyperthyroidism and hypothyroidism. Clinical indexes effectively monitored thyroid function in these cardiac arrhythmia patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Context:

  • Amiodarone is a widely used antiarrhythmic drug.
  • Chronic amiodarone use is associated with various adverse effects, including thyroid dysfunction.
  • Monitoring thyroid function is crucial in patients receiving long-term amiodarone therapy.

Purpose:

  • To determine the incidence of new-onset thyroid dysfunction in patients chronically treated with amiodarone for cardiac arrhythmias.
  • To evaluate the utility of clinical indexes in monitoring thyroid function during amiodarone therapy.
  • To assess the prevalence of amiodarone-induced hyperthyroidism and hypothyroidism.

Summary:

  • A prospective study followed 132 patients without prior thyroid issues on chronic amiodarone for cardiac arrhythmias.

Related Experiment Videos

  • Thyroid status was monitored using clinical indexes and biochemical tests over a mean follow-up of 20 months.
  • The incidence of new thyroid dysfunction was 3%, with equal rates of hyperthyroidism and hypothyroidism, consistent with adequate iodine intake.

    • Impact:

    • Clinical indexes are a useful and economical method for monitoring thyroid function in amiodarone-treated patients.
    • Early detection of thyroid dysfunction can prevent serious complications.
    • Findings support routine thyroid function monitoring in patients on long-term amiodarone therapy.