Related Experiment Video
Updated: May 12, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
Periprosthetic joint infection: Current concept
Vinay K Aggarwal1, Mohammad R Rasouli, Javad Parvizi
1Department of Adult Reconstruction Surgery, Rothman Institute of Orthopaedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Abstract:
Periprosthetic joint infection (PJI) is one of the most devastating and costly complications following total joint arthroplasty (TJA). Diagnosis and management of PJI is challenging for surgeons. There is no "gold standard" for diagnosis of PJI, making distinction between septic and aseptic failures difficult. Additionally, some of the greatest difficulties and controversies involve choosing the optimal method to treat the infected joint. Currently, there is significant debate as to the ideal treatment strategy for PJI, and this has led to considerable international variation in both surgical and nonsurgical management of PJI. In this review, we will discuss diagnosis and management of PJI following TJA and highlight some recent advances in this field.
Insights
Diagnosing and treating periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) is complex. This review covers current challenges and recent advances in PJI diagnosis and management.
Area of Science:
- Orthopedic surgery
- Infectious diseases
- Biomedical engineering
Background:
- Periprosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA).
- Accurate diagnosis of PJI is challenging due to the lack of a gold standard, complicating the differentiation between septic and aseptic joint failures.
- Optimal treatment strategies for PJI remain a subject of significant debate and international variation.
Purpose of the Study:
- To review the current diagnostic methods for PJI.
- To discuss the various management strategies for PJI.
- To highlight recent advancements in the field of PJI diagnosis and treatment.
Main Methods:
- Literature review of diagnostic criteria for PJI.
- Analysis of current surgical and non-surgical treatment options for PJI.
- Examination of recent research and technological advancements relevant to PJI.
Main Results:
- No single diagnostic test is universally accepted for PJI.
- Treatment decisions for PJI involve complex considerations with varied international approaches.
- Ongoing research is exploring novel diagnostic tools and therapeutic interventions for PJI.
Conclusions:
- Effective diagnosis and management of PJI remain critical challenges in orthopedic surgery.
- Further research and standardization of diagnostic and treatment protocols are needed to improve patient outcomes for PJI.
- Recent advances offer promise for more accurate PJI diagnosis and tailored treatment strategies.
Related Concept Videos
Endocarditis I: Introduction
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Endocarditis III: Medical Management
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Pyelonephritis I: Introduction
Endocarditis IV: Nursing Management

