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Related Experiment Videos

Blood cell filtrability: reference values and clinical applications.

A Belboul1, N al-Khaja, P Bergman

  • 1Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, University of Göteborg, Gothenburg, Sweden.

Scandinavian Journal of Clinical and Laboratory Investigation
|May 1, 1990
PubMed
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Cell deformability decreases with age, impacting red blood cell filtration rate (RFR). This study establishes reference values and shows significant reductions in various patient groups, indicating impaired cell function.

Area of Science:

  • Hematology
  • Physiology
  • Medical Diagnostics

Background:

  • Cell deformability is a critical factor in microcirculation.
  • Age and certain diseases are known to affect cell properties.
  • Establishing reference values for cell filtration is essential for diagnostic purposes.

Purpose of the Study:

  • To determine reference values for cell filtration rate (RFR) in healthy adults across different age groups.
  • To investigate the impact of aging on cell deformability.
  • To assess changes in cell deformability in patients with specific medical conditions.

Main Methods:

  • A microcirculation method was employed to measure cell filtration rates.
  • 500 healthy individuals were studied to establish normal ranges.

Related Experiment Videos

  • Red blood cell filtration rate (RFR), white cell filtration rate (WFR), plasma-white cell filtration rate (P-WFR), and whole-blood filtration rate (WBFR) were measured.

    • Main Results:

    • The overall normal RFR in healthy individuals was 69 +/- 11 microliters/s.
    • Significant reductions in RFR, WFR, P-WFR, and WBFR were observed between younger (20-29 years) and older (60-69 years) age groups.
    • Patients with heart surgery, cardiac arrest, occlusive arterial disease, and diabetes exhibited significantly reduced RFR, with none having normal values.

    Conclusions:

    • Cell deformability demonstrably decreases with advancing age.
    • Various pathological conditions, including cardiovascular diseases and diabetes, are associated with impaired cell deformability.
    • The study highlights the clinical relevance of cell filtration rate as an indicator of cell health and microcirculatory function.