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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
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Cancer stem cell and stromal microenvironment.

Li Li1, John Cole, David A Margolin

  • 1Institute for Translational Research, Laboratory of Translational Cancer Research.

Ochsner Journal
|March 28, 2013
PubMed
Summary
This summary is machine-generated.

Chemotherapy resistance and cancer recurrence are major challenges. Targeting cancer stem cells and the tumor microenvironment may offer new strategies to minimize recurrence and improve patient outcomes.

Keywords:
Cancer metastasiscancer stem cellsdrug resistancestromal cellstumor microenvironment

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Published on: May 11, 2016

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • Chemotherapeutic resistance, local recurrence, and distant metastasis are primary drivers of cancer mortality.
  • Conventional cancer treatments often fail to prevent cancer recurrence.
  • Understanding resistance mechanisms is crucial for improving patient survival rates.

Purpose of the Study:

  • To elucidate the roles of cancer stem cells and the tumor microenvironment in cancer drug resistance, metastasis, and recurrence.
  • To highlight the significance of the lymph node stromal microenvironment in these processes.
  • To identify potential therapeutic targets for overcoming treatment resistance.

Main Methods:

  • Focused on two distinct cancer types: colorectal cancer and follicular lymphoma.
  • Illustrated the interplay between cancer stem cells and the tumor microenvironment.
  • Examined the specific contributions of the lymph node stromal microenvironment.

Main Results:

  • Cancer stem cells significantly contribute to therapeutic resistance.
  • The tumor microenvironment, particularly lymph node stroma, plays a critical role in metastasis and recurrence.
  • These factors are key determinants of treatment failure and disease progression.

Conclusions:

  • Combination therapy involving chemotherapeutic agents and targeted treatments is a promising approach.
  • Targeting stromal and cancer stem cell signaling pathways may effectively minimize cancer recurrence.
  • This strategy holds potential for improving long-term patient outcomes by preventing disease relapse.