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Related Experiment Video

Updated: May 12, 2026

Transcranial Electrical Brain Stimulation in Alert Rodents

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

Crying with sorrow evoked by electrocortical stimulation.

Tyson Burghardt¹, Maysaa M Basha, Darren Fuerst

¹Department of Neurology, Wayne State University, Detroit, MI 48201, USA.

Epileptic Disorders : International Epilepsy Journal with Videotape

|March 28, 2013

Summary

Dacrystic seizures, characterized by crying, are rare epilepsy symptoms. This study details the first instance of inducing such seizures via direct brain stimulation in a patient with left temporal lobe epilepsy.

Keywords:

cortical stimulation dacrystic seizures extraoperative intracranial video-EEG subdural electrode implantation

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Last Updated: May 12, 2026

Transcranial Electrical Brain Stimulation in Alert Rodents

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Published on: November 2, 2017

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

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Published on: October 22, 2015

Area of Science:

Neuroscience
Epileptology
Clinical Neurology

Background:

Dacrystic seizures are infrequent epilepsy manifestations, typically associated with hypothalamic hamartoma or fronto-temporal epilepsy in the non-dominant hemisphere.
The exact neurobiological underpinnings and potential for direct induction remain largely unexplored.

Observation:

A 41-year-old female patient with medically intractable left temporal lobe epilepsy underwent intracranial video-EEG monitoring.
Cortical stimulation was applied to the left posterior orbito-frontal gyrus during extraoperative monitoring.

Findings:

Direct cortical stimulation of the left posterior orbito-frontal gyrus reproducibly elicited dacrystic seizures with clear affective content.
This represents the first reported case of inducing dacrystic seizures through direct brain stimulation.

Implications:

This finding suggests the left posterior orbito-frontal gyrus plays a crucial role in the generation of dacrystic seizures.
It may offer new insights into the neural circuitry of emotional expression and epilepsy.
Potential implications for surgical targeting and understanding non-lesional epilepsy.