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Updated: May 12, 2026

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Published on: March 11, 2020
Progressive presynaptic dopaminergic deterioration in Huntington disease: a [123I]-FP-CIT SPECT two-year follow-up
Josep Gamez1, Carles Lorenzo-Bosquet, Gemma Cuberas-Borrós
1From the *Neurology Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), and †Servei de Medicina Nuclear, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain; and ‡Department of Statistics, University of Barcelona, Barcelona, Spain.
Abstract:
To illustrate the potential of [I]-FP-CIT SPECT DaTSCAN® in investigating the progression of presynaptic dopaminergic degeneration in Huntington disease (HD), we performed a 2-year follow-up [I]-FP-CIT study on 4 HD patients, evaluating the SPECT imaging based on qualitative and semiquantitative analysis. The mean annual decline in [I]-FP-CIT uptake in caudate and putamen after 2 years of follow-up was 5.8% and 9.6%, respectively. Our findings suggest that [I]-FP-CIT SPECT is useful in investigating the progression of presynaptic dopaminergic degeneration in HD, and may be useful as a disease biomarker, providing an objective method for measuring the effectiveness of future neuroprotective therapies.
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