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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Risk of nocardial infections with anti-tumor necrosis factor therapy
Tauseef Ali1, Amarsha Chakraburtty, Sultan Mahmood
1OU Physicians Center for Inflammatory Bowel Disease, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Tauseef-ali@ouhsc.edu
Abstract:
Anti-tumor necrosis factor (anti-TNF) therapy is beneficial in the management of many chronic immune-mediated inflammatory diseases. However, its use is associated with increased risk of bacterial, fungal and viral infections. We present a case of cutaneous nocardiosis that occurred in a 61-year-old man, whose Crohn's disease was treated for nearly 1.5 years with infliximab. Prompt therapy with trimethoprim-sulfamethoxazole led to complete resolution. Only few cases of nocardiosis complicating anti-TNF therapy are reported in the literature. We present the case report and summary of the available literature with updates on the management and the treatment of the disease.
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