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[Enzyme activity in the normal atrioventricular node and in the bundle of His in young children]
1Oddĕlení soudního lékarství FDL KU.
Soudni Lekarstvi
|March 1, 1990
Insights
Histochemical analysis revealed that the atrioventricular node and bundle of His in infants exhibit lower oxidation capacity and higher pentose-phosphate shunt activity compared to adult working muscle.
Area of Science:
- Cardiovascular Histology
- Pediatric Pathology
- Biochemistry
Context:
- The study investigates the histochemical properties of the cardiac conduction system in infants.
- Comparison is made between immature and adult cardiac tissues.
Purpose:
- To characterize the histochemical profile of the atrioventricular node and bundle of His in infants.
- To compare these findings with those in adult cardiac tissues.
Summary:
- Histochemical methods were used to examine the atrioventricular node and bundle of His in infants.
- These structures showed lower oxidation capacity, higher pentose-phosphate shunt activity, and high acetylcholine esterase activity, similar to adult findings.
Impact:
- Provides insights into the developmental maturation of the cardiac conduction system.
- Contributes to understanding potential age-related differences in cardiac electrophysiology.
Abstract:
The authors examined by histochemical methods the atrioventricular node and the bundle of His in five infants who died from unnatural deaths and in a four-and-half-year-old child who died immediately following haemorrhagic infarction of the gut. Both structures differed, similarly as in adult age, from working muscle by a lower oxidation capacity, higher activity of the pentose-phosphate shunt and a high acetylcholine esterase activity.