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Updated: May 12, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Canine prostatic carcinoma.

Sandra M Axiak¹, Astrid Bigio

¹University of Missouri, USA.

Compendium (Yardley, PA)

|March 28, 2013

Summary

Canine prostatic carcinoma is aggressive and spreads to other organs. Enlarged, mineralized prostates in castrated dogs may indicate this cancer, requiring multimodal treatment for better quality of life.

Area of Science:

Veterinary oncology
Canine cancer research

Background:

Canine prostatic carcinoma is a locally aggressive cancer.
It has a high propensity for metastasis to lymph nodes, lungs, liver, spleen, and bone.

Purpose of the Study:

To review the staging and treatment of canine prostatic carcinoma.
To highlight key diagnostic findings and therapeutic considerations.

Main Methods:

Review of current literature on canine prostatic carcinoma.
Discussion of diagnostic imaging modalities (radiography, ultrasonography).
Overview of treatment strategies including NSAIDs and other therapies.

Main Results:

Common metastatic sites are well-defined.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Murine Prostate Micro-dissection and Surgical Castration

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Published on: May 11, 2016

Prostatic enlargement and mineralization in castrated males are significant indicators.

NSAIDs are crucial for pain management.

Conclusions:

Accurate staging is essential for treatment planning.
Multimodal therapeutic approaches are necessary to improve patient quality of life.
Early identification of canine prostatic carcinoma improves prognosis.