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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
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Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Protein Networks02:26

Protein Networks

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Peptidomic Profiling Reveals Extracellular Matrix Remodeling Signatures Discriminative of Multiple Myeloma.

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Urinary Peptidomic Signatures Predict Overall and Progression-Free Survival in Bladder Cancer.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Network views for personalized medicine.

Antonia Vlahou1

  • 1Division of Biotechnology, Biomedical Research Foundation, Academy of Athens, 15527 Athens, Greece. vlahoua@bioacademy.gr

Proteomics. Clinical Applications
|March 28, 2013
PubMed
Summary
This summary is machine-generated.

Clinical proteomics shows promise for disease biomarkers, but implementation requires better validation and open-minded collaboration. Multidisciplinary networks are crucial for advancing biomarker development, especially in bladder cancer research.

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Area of Science:

  • Proteomics
  • Biomarker Discovery
  • Clinical Implementation

Background:

  • Clinical proteomics has identified numerous potential disease biomarkers.
  • Lack of clinical implementation highlights issues in current biomarker discovery and validation practices.

Purpose of the Study:

  • To reflect on challenges in clinical proteomics and biomarker implementation.
  • To advocate for multidisciplinary networks in biomarker development, using bladder cancer as a model.

Main Methods:

  • Review of current practices in biomarker discovery and verification.
  • Discussion of challenges including resource needs, context of use, and data reporting.
  • Emphasis on the need for open-minded approaches and collaborative networks.

Main Results:

  • Biomarker discovery is advanced, but clinical translation remains a bottleneck.
  • Current practices require re-evaluation regarding verification and data reporting guidelines.
  • Multidisciplinary networks are essential for efficient information exchange and resource sharing.

Conclusions:

  • Progress in biomarker implementation necessitates a shift towards collaborative, disease-focused networks.
  • Adoption of an open-minded approach and shared clinical resources will accelerate biomarker validation.
  • Multidisciplinary collaboration is key to overcoming hurdles in translating proteomics findings into clinical practice, exemplified by bladder cancer research.