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Related Experiment Video

Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Cortical abnormalities in patients with migraine: a surface-based analysis.

Roberta Messina1, Maria A Rocca, Bruno Colombo

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy.

Radiology
|March 28, 2013
PubMed
Summary

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Migraine patients exhibit altered cortical thickness and surface area, with abnormalities linked to aura and white matter hyperintensities. These changes may reflect both inherent predispositions and disease-related processes.

Area of Science:

  • Neuroimaging
  • Neurology
  • Brain Anatomy

Background:

  • Migraine is a complex neurological disorder.
  • Cortical structure alterations are implicated in migraine pathogenesis.
  • Understanding these changes is crucial for disease management.

Purpose of the Study:

  • To investigate cortical thickness and surface area abnormalities in migraineurs.
  • To correlate these abnormalities with clinical and radiologic features.
  • To differentiate between intrinsic predisposition and disease-related changes.

Main Methods:

  • Brain MRI (T1- and T2-weighted) in 63 migraineurs and 18 controls.
  • Vertex-by-vertex analysis of cortical thickness and surface area.
  • Statistical modeling to compare groups and assess correlations.

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Related Experiment Videos

Last Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Cortical Source Analysis of High-Density EEG Recordings in Children
09:32

Cortical Source Analysis of High-Density EEG Recordings in Children

Published on: June 30, 2014

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Main Results:

  • Migraineurs showed reduced cortical thickness/surface area in pain processing regions.
  • Increased metrics observed in executive function and visual motion processing areas.
  • Abnormalities correlated with aura and white matter hyperintensities, not disease duration or frequency.

Conclusions:

  • Cortical abnormalities are present in migraineurs.
  • Surface area changes may indicate intrinsic predisposition.
  • Thickness changes might reflect disease-related processes.