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The serum IL-6 profile and Treg/Th17 peripheral cell populations in patients with type 1 diabetes
Monika Ryba-Stanisławowska1, Maria Skrzypkowska, Jolanta Myśliwska
1Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland. akinomab@gumed.edu.pl
Abstract:
IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.
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