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Postpartum acquired hemophilia: a rare cause of postpartum hemorrhage

Srikanth Seethala1, Sumit Gaur, Elizabeth Enderton

  • 1Department of Internal Medicine, University of New Mexico-Albuquerque, 1 University of New Mexico, MSC10 555, Albuquerque, NM 87131, USA.

Case Reports in Hematology
|March 28, 2013
PubMed

A 36-year-old female started having postpartum vaginal bleeding after normal vaginal delivery. She underwent hysterectomy for persistent bleeding and was referred to our institution. An elevation of PTT and normal PT made us suspect postpartum acquired hemophilia (PAH), and it was confirmed by low factor VIII activity levels and an elevated factor VIII inhibitor. Hemostasis was achieved with recombinant factor VII concentrates and desmopressin, and factor eradication was achieved with cytoxan, methylprednisolone, and plasmapheresis.

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