[Heterogeneity of chromosomal abnormalities in acute myeloid leukemia in different age groups children]

Characteristic of chromosomal abnormalities in bone marrow cells among 123 children with acute myeloid leukemia were presented according five aging groups: I - up to 2 years, II - 2-5 years, III - 5-10 years, IV - 10-15 years, V - 15-18 years. Normal karyotype wasn't found in group up to 2 years and in low presented in another groups (5, 9-10,3%). The highest frequency of chromosomal abnormality evolution in group up to 2 years was established (69,2%). The highest frequency of hyperdiploidy (47-50 chromosomes) in group 15-18 years (31%) was found. More often near-tetraploidy and pseudodiploidy clones were met in group 2-5 years (47% and 58,8%, respectively). Between structural types in all groups were predominated translocations and deletions. In group up to 2 years was prevalented translocations (61,5%), 2-18 years - deletions (64,7; 34,5; 45,7 and 41,4 % respectively). In group up to 2 years more often were met abnormalities chromosomes (Chr) 9, 11, 16 (in 30,8%), 2-5 years - Chr 16, 21 (in 29,4%), 5-10 years - Chr 11 (24,1%), 8, 15, 17 (in 17,2%), 10-15 years - Chr 16 (40%) and 15-18 years - Chr 8, 9, 15, 17 (in 17,2%).