[A method of modified neuroleptanalgesia in lung surgery]

A modification of neuroleptanalgesia (NLA) has been developed to be applied in operations on the lungs. It is based on the inclusion of indomethacin and diazepam into premedication, on the bolus administration of phentanyl, droperidol, and diazepam prior to the most traumatic stages of the operation, and on the subsequent infusion of phentanyl and droperidol. The modified technique of NLA has been applied in operations on 19 patients with lung cancer. The control (traditional NLA technique) consisted of 20 lung cancer patients. Evaluation of the endocrine response and venous blood plasma concentration of metabolites of polyunsaturated fatty acids showed a possibility for reducing the stress response to the operative trauma by using the modified NLA technique. The advantages of this method are well demonstrated in the course of the postoperative period as a lowered incidence of postoperative inflammatory complications.