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SYK regulates mTOR signaling in AML

J Carnevale1, L Ross, A Puissant

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

Leukemia
|March 29, 2013
PubMed
Summary

Spleen tyrosine kinase (SYK) regulates key signaling pathways in acute myeloid leukemia (AML). Inhibiting SYK impacts mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways, affecting AML cell growth.

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