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Updated: May 12, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Inflammation does not influence arterial stiffness and pulse-wave velocity in patients with coronary artery disease

A D Blann1, N Kuzniatsova, G Y H Lip

  • 1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.

Journal of Human Hypertension
|March 29, 2013
PubMed

Insights

In stable coronary artery disease patients, arterial stiffness and pulse pressure are primarily linked to age and blood pressure, not inflammation. Inflammatory markers showed minimal impact on vascular function in this study.

Area of Science:

  • Cardiovascular Disease Research
  • Vascular Physiology
  • Inflammation Biology

Background:

  • Vascular function is crucial in cardiovascular disease pathogenesis.
  • Hypertension and inflammation are potential risk factors influencing vascular health.
  • Arterial stiffness and pulse pressure are key indicators of vascular function and hemodynamics.

Purpose of the Study:

  • To investigate the relationship between inflammatory markers, hypertension, and vascular function in stable coronary artery disease (CAD) patients.
  • To assess the independent contributions of inflammation, age, and blood pressure to arterial stiffness and pulse pressure.

Main Methods:

  • Recruited 222 stable CAD outpatients.
  • Measured inflammatory markers: high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6).
  • Assessed vascular function via pulse-wave velocity (PWV), augmentation index, aortic/brachial pulse pressure, Von Willebrand factor (vWf), and soluble E-selectin.

Main Results:

  • Pulse-wave velocity (PWV), augmentation indices, and pulse pressures were significantly associated with age, blood pressure, and heart rate (P<0.01).
  • Von Willebrand factor (vWf) showed an association with age (P=0.01).
  • Inflammatory markers (hs-CRP, IL-6) demonstrated minimal independent association with the measured vascular function parameters.

Conclusions:

  • In stable CAD patients, arterial stiffness and pulse pressure are strongly and independently determined by age, blood pressure, and heart rate.
  • The influence of inflammation on vascular function, as assessed by these markers, appears minimal in this patient cohort.

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