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Intravitreal ganciclovir for neonatal cytomegalovirus-associated retinitis: a case report

A Oschman1, V Murthy, R Kollipara

  • 1Department of Pharmacy, Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA. aoschman@cmh.edu

Journal of Perinatology : Official Journal of the California Perinatal Association
|March 29, 2013
PubMed

Insights

Congenital cytomegalovirus (CMV) retinitis can cause vision loss in newborns. This case study shows intravitreal ganciclovir may be a safe and effective treatment option for neonates with this condition.

Area of Science:

  • Ophthalmology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Congenital cytomegalovirus (CMV) infection is a leading cause of congenital disabilities.
  • CMV retinitis (CMVR) affects a significant percentage of infants with congenital CMV.
  • Intravitreal ganciclovir is a standard treatment for CMVR in adults but its use in neonates is not documented.

Observation:

  • A case report of a term neonate diagnosed with CMVR.
  • The neonate received both intravenous and intravitreal ganciclovir.
  • Three doses of intravitreal ganciclovir (2 mg per eye) were administered.

Findings:

  • Intravitreal ganciclovir treatment was well-tolerated in the neonate.
  • Improvement in the infant's retinitis was observed following treatment.
  • This suggests intravitreal ganciclovir may be effective for treating CMVR in neonates.

Implications:

  • This case suggests a potential new treatment approach for CMVR in neonates.
  • Further research is warranted to confirm the efficacy and safety of intravitreal ganciclovir in this population.
  • This could lead to improved visual outcomes for infants with congenital CMV infection.

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