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Updated: May 12, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

The UPR and lung disease.

Fabiola Osorio¹, Bart Lambrecht, Sophie Janssens

¹GROUP-ID Consortium, Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University Hospital, Ghent, Belgium.

Seminars in Immunopathology

|March 29, 2013

Summary

This summary is machine-generated.

Endoplasmic reticulum (ER) stress impacts lung health by affecting airway epithelial cells, immune cells, and structural cells. This review explores ER stress

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Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Area of Science:

Pulmonary Medicine
Cellular Biology
Immunology

Background:

The respiratory tract's large surface area and daily air intake expose lung cells to environmental triggers.
Inhaled pollutants like smoke and allergens induce endoplasmic reticulum (ER) stress, disrupting cellular homeostasis.
Secretory lung cells and immune cells are particularly vulnerable to unresolved ER stress.

Purpose of the Study:

To review the multifaceted role of ER stress in lung health and disease.
To examine the impact of ER stress on various lung cell types, including structural and inflammatory cells.

Main Methods:

Literature review focusing on endoplasmic reticulum (ER) stress pathways in the lung.
Analysis of how ER stress affects epithelial, vascular smooth muscle, fibroblast, and immune cells.
Exploration of the intersection between unfolded protein response signaling and immune cell function.

Main Results:

ER stress dysregulates ER homeostasis in airway epithelium, impacting secretory functions.
ER stress triggers aberrant dedifferentiation and proliferation in lung interstitial cells.
Unfolded protein response signaling pathways significantly influence immune cell function in the lung.

Conclusions:

ER stress is a critical factor in lung pathophysiology, affecting diverse cell types.
Understanding ER stress mechanisms is key to addressing lung diseases.
Further research into ER stress modulation could offer therapeutic strategies for respiratory conditions.