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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

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Published on: July 14, 2023

Intrinsic connectivity network disruption in progressive supranuclear palsy.

Raquel C Gardner¹, Adam L Boxer, Andrew Trujillo

¹Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Annals of Neurology

|March 29, 2013

Summary

This study identifies a specific brain network disrupted in progressive supranuclear palsy (PSP). Network connectivity changes in PSP patients correlate with disease severity, offering new insights into this neurological disorder.

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Area of Science:

Neuroscience
Neurology
Medical Imaging

Background:

Progressive supranuclear palsy (PSP) is understood as a large-scale brain network disruption.
The precise network affected in PSP remains incompletely defined.

Purpose of the Study:

To characterize the specific brain network impacted in individuals with clinical PSP.
To delineate the intrinsic connectivity network associated with the dorsal midbrain tegmentum (dMT) in healthy individuals and compare it to PSP patients.

Main Methods:

Task-free functional magnetic resonance imaging (fMRI) was employed to map intrinsic connectivity to the dMT.
Connectivity patterns in healthy young and older adults were established and replicated.
Patients with PSP were compared to an independent, matched healthy control group.

Main Results:

A consistent pattern of dMT connectivity was observed in healthy subjects, involving brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions.
Patients with PSP exhibited significant disruptions in this network, particularly in corticosubcortical and cortico-brainstem connections.
Reduced dMT network connectivity scores were associated with greater functional impairment in PSP patients.

Conclusions:

A distinct PSP-related intrinsic connectivity network has been defined in the healthy brain.
Network-based imaging methods are sensitive to PSP-related physiological and clinical alterations.
This research provides a foundation for understanding PSP as a network disorder.