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[Hyperoxemia in extracorporeal circulation].

C Chartrand, L Langevin, F Forest

    Canadian Journal of Surgery. Journal Canadien De Chirurgie
    |January 1, 1975
    PubMed
    Summary
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    Hyperoxia during extracorporeal circulation in dogs did not improve outcomes but increased red blood cell breakdown (hemolysis). Maintaining high arterial oxygen levels (Po2) above 200 mm Hg is not beneficial and elevates hemolysis.

    Area of Science:

    • Cardiovascular Surgery
    • Physiology
    • Biochemistry

    Context:

    • Extracorporeal circulation (ECC) is a life support system used during cardiac surgery.
    • Hyperoxemia, or elevated blood oxygen levels, is sometimes employed during ECC.
    • The safety and efficacy of hyperoxemia during ECC require further investigation.

    Purpose:

    • To investigate the effects of hyperoxemia on dogs undergoing total body bypass.
    • To compare outcomes between dogs with normal arterial Po2 (100-140 mm Hg) and those with hyperoxemia (Po2 > 200 mm Hg).

    Summary:

    • Dogs undergoing ECC were divided into two groups: one with normal arterial Po2 and another with hyperoxemia.
    • No significant differences in postoperative functional status, hematological, or biochemical data were observed between groups.

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  • Free plasma hemoglobin levels were 50% higher in the hyperoxemia group, indicating increased hemolysis.

    • Impact:

    • Hyperoxemia during total body bypass does not offer benefits.
    • Arterial Po2 levels exceeding 200 mm Hg during ECC can lead to increased hemolysis.
    • These findings suggest that maintaining normoxia is preferable during extracorporeal circulation to minimize red blood cell damage.