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Redox Reactions

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Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

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Published on: December 23, 2016

Redox-Responsive, Core Cross-Linked Polyester Micelles.

Zhonghai Zhang¹, Lichen Yin, Chunlai Tu

¹Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL, 61801, USA ; Institute of Nano- and Bio-polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, 200092, China.

ACS Macro Letters

|March 29, 2013

Summary

This summary is machine-generated.

Biodegradable polyester micelles were created using a novel block copolymer and click chemistry. These core cross-linked micelles offer enhanced stability and controlled drug release, showing promise for drug delivery applications.

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

Polymer Chemistry
Materials Science
Nanotechnology

Background:

Biodegradable amphiphilic block copolymers are crucial for developing advanced drug delivery systems.
Polyester micelles offer potential for encapsulating and releasing therapeutic agents.
Click chemistry provides efficient and specific methods for polymer modification and network formation.

Purpose of the Study:

To synthesize a novel biodegradable amphiphilic block copolymer: Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA).
To utilize this copolymer to create core cross-linked polyester micelles through click chemistry.
To evaluate the structural stability and cargo release properties of the developed micelles.

Main Methods:

Synthesis of Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA) via ring-opening polymerization.
Preparation of core cross-linked polyester micelles using click chemistry.
Assessment of micelle structural stability and controlled release triggered by reducing reagents.

Main Results:

Successful synthesis of the biodegradable amphiphilic block copolymer.
Formation of stable, core cross-linked polyester micelles.
Demonstrated controlled release of cargo molecules in response to a reducing environment.

Conclusions:

The synthesized block copolymer effectively forms stable core cross-linked polyester micelles.
These micelles exhibit controlled release capabilities, making them suitable for drug delivery.
This new class of micelles represents a promising platform for advanced therapeutic applications.