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Updated: May 12, 2026
04:30
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
[Sclerodegenerative aortic valve lesions and hereditary connective tissue disorders]
Terapevticheskii Arkhiv
|March 29, 2013
Summary
Bone dysmorphogenesis and Marfanoid habitus are predictors of sclerodegenerative aortic valve lesions (SDAVL). Three or more bone dysmorphogenesis signs indicate increased risk for SDAVL development.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Rheumatology
Background:
- Sclerodegenerative lesions and calcific stenosis of the aortic valve (AV) are significant health concerns.
- The role of dysplastic syndromes and phenotypes in AV disease development requires further investigation.
Purpose of the Study:
- To estimate the role of different dysplastic syndromes and phenotypes in the development of sclerodegenerative lesions and calcific stenosis of the aortic valve (AV).
Main Methods:
- Examined 150 patients (89 with sclerodegenerative AV lesions (SDAVL), 61 controls).
- Included patients aged 42-83 years.
- Histological examination of 25 valves from patients with critical calcific aortic stenosis (CAS).
Main Results:
- Marfanoid habitus (18%) and mitral valve prolapse (10.7%) were common in older age groups.
- An association was found between bone signs of dysmorphogenesis and the development of SDAVL and CAS.
Conclusions:
- Three or more signs of bone dysmorphogenesis, along with Marfanoid habitus, should be considered a predictor of SDAVL.
- These findings highlight the link between connective tissue disorders and aortic valve disease.
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