Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relapsing Clostridium difficile colitis and Reiter's syndrome.

R S Hayward1, R H Wensel, P Kibsey

  • 1Department of Medicine, University of Alberta, Edmonton, Canada.

The American Journal of Gastroenterology
|June 1, 1990
PubMed
Summary

Clostridium difficile infection can trigger Reiter's syndrome, characterized by arthritis and urethritis, in susceptible individuals. This case suggests C. difficile toxins are not directly responsible for the joint inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outbreak of invasive <i>Streptococcus pneumoniae</i> among an inner-city population in Victoria, British Columbia, 2016-2017.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2019
Same author

Utilization of computerized clinical decision support for potentially inappropriate medications.

Clinical interventions in aging·2019
Same author

Bacterial RNA polymerases: structural and functional relationships.

World journal of microbiology & biotechnology·2014
Same author

Complete sequences of a novel blaNDM-1-harbouring plasmid from Providencia rettgeri and an FII-type plasmid from Klebsiella pneumoniae identified in Canada.

The Journal of antimicrobial chemotherapy·2013
Same author

Carbapenem-resistant Gram-negative bacilli in Canada 2009-10: results from the Canadian Nosocomial Infection Surveillance Program (CNISP).

The Journal of antimicrobial chemotherapy·2012
Same author

Containing cefoxitin costs through a program to curtail use in surgical prophylaxis.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Recurrent Clostridium difficile-associated colitis can present with extraintestinal manifestations.
  • Reiter's syndrome, a reactive arthritis, is associated with HLA-B27 positivity.

Observation:

  • A patient with recurrent C. difficile colitis experienced severe arthritis and urethritis with each episode.
  • Immune complexes were found in synovial fluid, but antibodies to C. difficile toxins were absent.
  • The patient was HLA-B27 positive and developed symptoms including sacroiliitis, tenosynovitis, and oligoarthritis.

Findings:

  • Symptoms resolved with successful treatment of C. difficile colitis, indicating a strong temporal link.
  • The patient's presentation suggests C. difficile infection may precipitate Reiter's syndrome.

Related Experiment Videos

  • Evidence does not support a role for antibodies to C. difficile toxins in the joint inflammation.

    • Implications:

    • This case supports the hypothesis that C. difficile infection can trigger Reiter's syndrome.
    • Further research is needed to elucidate the mechanisms linking C. difficile infection to reactive arthritis.
    • Understanding this association may lead to improved diagnostic and therapeutic strategies for patients with recurrent C. difficile and reactive arthritis.