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Exploring drug delivery systems for treating osteoporosis
Mohammad Fazil1, Asgar Ali, Sanjula Baboota
1Jamia Hamdard, Faculty of Pharmacy, Department of Pharmaceutics, Hamdard Nagar, New Delhi-110062, India.
Expert Opinion on Drug Delivery
|March 30, 2013
Summary
Osteoporosis (OP) is a growing global health issue, particularly in the elderly, leading to fractures. Advanced drug delivery systems offer improved bone targeting and reduced side effects for better osteoporosis treatment.
Area of Science:
- Bone biology and pharmacology
- Drug delivery systems
- Osteoporosis research
Background:
- Osteoporosis (OP) is a significant health concern in aging populations, marked by increasing prevalence and complications.
- OP leads to fragility fractures, primarily affecting the hip, wrist, and spine, with projected increases in hip fractures globally.
- The societal impact of bone diseases necessitates urgent attention and innovative solutions.
Purpose of the Study:
- To review current knowledge on osteoporosis, its symptoms, and challenges with existing therapies.
- To explore various drug delivery systems designed for bone targeting in OP treatment.
- To compile in vitro and in vivo studies and identify US FDA-approved drugs for OP.
Main Methods:
- Literature review of osteoporosis and drug delivery systems.
- Compilation of in vitro and in vivo study findings.
- Analysis of US FDA-approved osteoporosis medications.
Main Results:
- Drug delivery systems can enhance drug availability at bone target sites and mitigate adverse effects.
- Ongoing research aims to refine osteoporosis treatment strategies.
- Conventional therapies may be complemented by novel therapeutic targets.
Conclusions:
- Targeted drug delivery systems show promise in improving osteoporosis management.
- Future research should focus on diverse therapeutic targets beyond conventional approaches.
- Addressing the rising prevalence and impact of osteoporosis requires innovative treatment strategies.
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