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Related Concept Videos

Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: May 12, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

NMDA receptor-dependent function and plasticity in inhibitory circuits.

Alexandre W Moreau1, Dimitri M Kullmann

  • 1UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

Neuropharmacology
|March 30, 2013
PubMed
Summary
This summary is machine-generated.

This review explores the role of N-methyl-D-aspartate (NMDA) receptors in the plasticity of inhibitory circuits. Understanding NMDA receptor function is crucial for comprehending healthy brain function and disorders like schizophrenia.

Keywords:
Inhibitory circuitsInterneuronsNMDA receptorsPlasticitySchizophrenia

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3D Modeling of Dendritic Spines with Synaptic Plasticity
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Related Experiment Videos

Last Updated: May 12, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
04:48

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate

Published on: July 10, 2018

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Molecular Biology

Background:

  • N-methyl-D-aspartate (NMDA) receptors are crucial for synaptic plasticity in principal cells.
  • Their role in inhibitory circuits is less understood due to GABAergic cell diversity.

Purpose of the Study:

  • To review recent evidence on NMDA receptor roles in GABAergic and glutamatergic synapses.
  • To explore NMDA receptor impact on information routing in inhibitory circuits.
  • To investigate NMDA receptor dysfunction in neurological disorders like schizophrenia.

Main Methods:

  • Anatomical studies
  • Immunohistochemistry
  • Electrophysiology
  • Literature review of recent evidence

Main Results:

  • Distinct GABAergic cell types are being identified.
  • Emerging patterns of synaptic plasticity in inhibitory circuits are being recognized.
  • NMDA receptors influence plasticity in both GABAergic and glutamatergic synapses.

Conclusions:

  • NMDA receptors are key players in the plasticity of inhibitory circuits.
  • Further research is needed to understand NMDA receptor function in health and disease.
  • Understanding NMDA receptor roles may offer insights into schizophrenia.