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Left ventricular mass in HIV-infected patients.
J Olalla1, M Pombo, A Del Arco
1Área de Medicina Interna, Agencia Sanitaria Costa del Sol, Consejería de Salud, Junta de Andalucía, Marbella, Málaga, España. julio.olalla@gmail.com
Revista Clinica Espanola
|March 30, 2013
Summary
HIV patients with higher vascular risk (VR10) and a history of nevirapine use showed increased left ventricular mass (LVM). This finding highlights potential cardiovascular complications in HIV management.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- HIV infection is linked to increased vascular events and higher left ventricular mass (LVM).
- Elevated LVM is an independent predictor of mortality.
- Previous studies indicate HIV-infected individuals have greater LVM than uninfected populations.
Purpose of the Study:
- To determine the distribution of LVM in a large cohort of HIV-infected patients.
- To identify factors associated with increased LVM in this population.
Main Methods:
- A cross-sectional study involving 400 HIV-infected patients.
- Transthoracic echocardiography (TTE) to measure LVM.
- Analysis of demographic, viroimmunological, cardiovascular risk factors, and antiretroviral drug history.
Main Results:
- Mean LVM was 39.54g/m(2.7) in 388 patients.
- Factors associated with increased LVM included age, BMI, hypertension, dyslipidemia, cardiovascular medications, and nevirapine use.
- Multivariate analysis identified VR10 and nevirapine use as significant factors.
Conclusions:
- Vascular risk at 10 years (VR10) may be associated with increased LVM in HIV patients.
- The association with nevirapine might be due to indication bias.
