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Related Experiment Videos

Microvascular changes in early and advanced dermatomyositis: a quantitative study.

A M Emslie-Smith1, A G Engel

  • 1Muscle Research Laboratory, Mayo Clinic, Rochester, MN 55905.

Annals of Neurology
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

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In dermatomyositis, capillaries show early damage and depletion, indicating they are a specific target of this autoimmune disease. Complement attack complex deposition in capillaries correlates with disease severity.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Adult dermatomyositis is an idiopathic inflammatory myopathy.
  • Muscle pathology in dermatomyositis is not fully understood, particularly early changes.

Purpose of the Study:

  • To investigate early vascular changes in dermatomyositis.
  • To determine if capillaries are a primary target in dermatomyositis pathogenesis.

Main Methods:

  • Paired immunofluorescence was used to visualize vascular endothelium and complement membrane attack complex (MAC) in muscle biopsies.
  • Capillary density and distribution were quantified in dermatomyositis, polymyositis, inclusion body myositis, and normal muscle.

Main Results:

  • Dermatomyositis muscle showed significant capillary depletion and reduced capillary density, even with minimal histological alterations.

Related Experiment Videos

  • Clusters of capillaries reacted positively for complement MAC in dermatomyositis, correlating with disease severity and poor outcomes.
  • Normal capillary density and absence of MAC deposition were observed in polymyositis, inclusion body myositis, and control muscle.

    • Conclusions:

    • Capillaries are an early and specific target in the pathogenesis of adult dermatomyositis.
    • Complement-mediated damage to capillaries may play a crucial role in dermatomyositis progression.