Related Experiment Video
Updated: May 12, 2026

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
Adaptogens in mental and behavioral disorders
1Research and Development, Swedish Herbal Institute, Kovlingevagen 21, Vallberga, Halland 31250, Sweden. ap@shi.se
This review covers Rhodiola rosea, Eleutherococcus senticosus, and Schisandra chinensis adaptogens. Evidence shows these herbs protect against stress and influence neuroendocrine functions.
Area of Science:
- Pharmacology
- Neuroendocrinology
- Herbal Medicine
Background:
- Adaptogens are natural substances that help the body resist stressors.
- Rhodiola rosea, Eleutherococcus senticosus, and Schisandra chinensis are well-researched adaptogens.
- The neuroendocrine system is crucial for stress response and metabolic regulation.
Purpose of the Study:
- To review the clinical evidence for three key adaptogens.
- To explore their stress-protective and simulative effects.
- To discuss their molecular mechanisms of action.
Main Methods:
- Literature review of clinical studies.
- Analysis of research on adaptogen effects.
- Examination of molecular pathways.
Main Results:
- Rhodiola rosea, Eleutherococcus senticosus, and Schisandra chinensis demonstrate stress-protective properties.
- These adaptogens modulate metabolic and neuroendocrine processes.
- Evidence supports their efficacy in managing stress responses.
Conclusions:
- The reviewed adaptogens show significant potential for stress management.
- Further research into their molecular mechanisms is warranted.
- These herbs may offer therapeutic benefits for stress-related conditions.
Related Concept Videos
Drug Therapy
Antianxiety Medications
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Antidepressant Drugs: MAOIs and Other Agents
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Stress Prevention and Stress Management Techniques III
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the risk...

