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Updated: May 12, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
Hepatitis B virus subgenotyping: history, effects of recombination, misclassifications, and corrections
Weifeng Shi1, Zhong Zhang, Cheng Ling
1School of Basic Medical Sciences, Taishan Medical College, Taian 271000, Shandong, China. wfshi.tsmc@gmail.com
Abstract:
Hepatitis B virus (HBV) has evolved into phylogenetically separable genotypes and subgenotypes. Accurately assigning the subgenotype for an HBV strain is of clinical and epidemiological significance. In this paper, we review the recommendations currently employed for HBV subgenotyping, the history of HBV subgenotyping, the effects of recombination on HBV subgenotyping, misclassifications in HBV subgenotyping, and suggestions are made to correct the misclassifications. Finally, proposals are made to guide future HBV subgenotyping.
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