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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Air pollution and heart failure: Relationship with the ejection fraction
Alberto Dominguez-Rodriguez1, Javier Abreu-Afonso, Sergio Rodríguez
1Alberto Dominguez-Rodriguez, Ruben A Juarez-Prera, Eduardo Arroyo-Ucar, Department of Cardiology, Hospital Universitario de Canarias, E-38320 Santa Cruz de Tenerife, Spain.
World Journal of Cardiology
|March 30, 2013
Summary
Short-term exposure to nitrogen dioxide air pollution is linked to hospital admissions for heart failure with preserved ejection fraction. This finding highlights the impact of air quality on cardiovascular health, particularly for vulnerable patient groups.
Area of Science:
- Environmental Health
- Cardiology
- Pulmonary Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) are distinct clinical entities.
- Ambient air pollution is a growing concern for cardiovascular disease exacerbations.
Purpose of the Study:
- To investigate the association between ambient air pollutant concentrations and hospital admissions for HFpEF and HFrEF.
- To identify specific pollutants linked to heart failure hospitalizations.
Main Methods:
- A cohort of 353 heart failure patients (HFpEF and HFrEF) was analyzed.
- Exposure to particulate matter (PM10, PM2.5, PM1) and gaseous pollutants (CO, SO2, NO2, O3) up to 7 days prior to admission was assessed.
- Multivariate analysis was used to determine significant predictors of admission.
Main Results:
- Patients with HFpEF experienced higher nitrogen dioxide (NO2) exposure compared to HFrEF patients.
- NO2 was identified as a significant independent predictor for HFpEF hospital admissions.
Conclusions:
- Short-term exposure to nitrogen dioxide is independently associated with hospital admission in patients with heart failure with preserved ejection fraction.
- Air quality, specifically NO2 levels, may play a critical role in triggering HFpEF exacerbations.
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