Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

TriAlignNet: A triple-path cross-modality alignment framework for multimodal time series forecasting.

Neural networks : the official journal of the International Neural Network Society·2026

Same author

Pyroptosis-associated inflammasome activation contributes to scleral remodeling in experimental myopia.

International journal of ophthalmology·2026

Same author

Spatial immune atlas of breast cancer brain metastasis reveals CD163<sup>+</sup> macrophage reprogramming associated with immune escape.

Journal for immunotherapy of cancer·2026

Same author

Machine learning models to predict the recurrence of common bile duct stones after ERCP.

BMC gastroenterology·2026

Same author

Comparative effectiveness of moxibustion-based combination therapies for lumbar disc herniation: a systematic review and network meta-analysis of 50 randomized trials.

Frontiers in neurology·2026

Same author

High frame rate action classification and state tracking in competitive sports using SlowFast dual-stream mesh structure.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

C-reactive protein and complement components in patients with pathological myopia.

Qin Long¹, Junjie Ye, Ying Li

¹Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. longqinbj@hotmail.com

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|March 30, 2013

Summary

This summary is machine-generated.

Pathological myopia (PM) is linked to inflammation. Higher C3 complement levels and age are risk factors for myopic choroidal neovascularization (mCNV) in PM patients.

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Efficient Dissection and Culture of Primary Mouse Retinal Pigment Epithelial Cells

Efficient Dissection and Culture of Primary Mouse Retinal Pigment Epithelial Cells

Published on: February 10, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Efficient Dissection and Culture of Primary Mouse Retinal Pigment Epithelial Cells

Efficient Dissection and Culture of Primary Mouse Retinal Pigment Epithelial Cells

Published on: February 10, 2021

Area of Science:

Ophthalmology
Immunology
Genetics

Background:

Pathological myopia (PM) is a severe form of myopia characterized by axial elongation and structural changes in the eye.
Myopic choroidal neovascularization (mCNV) is a major cause of vision loss in patients with PM.
The role of immunological and inflammatory markers in PM and mCNV development requires further investigation.

Purpose of the Study:

To examine the association between pathological myopia (PM) and immunological/inflammatory markers.
To identify potential risk factors contributing to the formation of myopic choroidal neovascularization (mCNV).

Main Methods:

Recruited 114 subjects: 63 with PM (spherical equivalent ≤ -8.00 D, axial length > 26.5 mm) and 51 emmetropic controls.
Assessed serum levels of high-sensitivity C-reactive protein (hs-CRP) and complement components (C3, C4, CH50).
Utilized binary logistic regression to identify risk factors for mCNV in PM patients.

Main Results:

PM patients exhibited significantly higher serum hs-CRP, C3, and CH50 compared to controls.
C3 complement levels (p = 0.03) and age (p = 0.01) were identified as significant risk factors for mCNV.
Serum hs-CRP, C4, CH50, and sex were not statistically significant predictors of mCNV.

Conclusions:

Immunological/inflammatory markers, including hs-CRP, C3, and CH50, are implicated in the pathogenesis of PM.
Serum C3 levels may serve as a predictive biomarker for the development of mCNV in pathological myopia.