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Related Experiment Videos

Is amiodarone good for heartburn?

D Martin1, B Lown

  • 1Department of Nutrition, Harvard University School of Public Health, Brookline, MA 02146.

Archives of Internal Medicine
|June 1, 1990
PubMed
Summary

Amiodarone therapy for cardiac arrhythmias may resolve severe esophagitis. This long-lasting effect might stem from amiodarone

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Pharmacology

Background:

  • Severe esophagitis with dyspepsia can be debilitating.
  • Cardiac arrhythmias often require antiarrhythmic drug therapy.

Observation:

  • Three patients with severe esophagitis and dyspepsia experienced symptom resolution.
  • These patients were undergoing amiodarone therapy for cardiac arrhythmias.

Findings:

  • Amiodarone therapy led to a long-lasting resolution of esophagitis.
  • Potential mechanisms include amiodarone's calcium antagonist or nitratelike properties affecting esophageal sphincter tone.
  • An alternative hypothesis suggests amiodarone may interact with histamine receptors, similar to ranitidine.

Implications:

  • Amiodarone may offer a novel therapeutic approach for refractory esophagitis.
  • Further research is warranted to elucidate the precise mechanism of action.
  • This finding could impact the management of patients with both cardiac arrhythmias and esophageal dysfunction.

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