[Structure of the liver after correction of experimental chronic hepatitis with benzonal and potassium orotate]

As a result of the experimental investigation of the liver damaged with CCL4, its essential structural changes have been revealed. They resemble those specific for a chronic toxic hepatitis. Administration of potassium orothate (100 mg/kg) increases proliferative activity of hepatocytes without any essential influence on intracellular regeneration. Under conditions of a delayed differentiation and lack of resorption of an abundantly outgrowing connective tissue, this results in a more profound pathological process in the liver. Benzonal administration (50 mg/kg) facilitates structural normalization of the chronically damaged liver, owing to activation of both cellular and intracellular regeneration.