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Updated: May 12, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Progressive symmetrical erythrokeratodermia -- case report.

Bianca de Mello Guaraldi¹, Thaís Jerez Jaime, Rafael de Mello Guaraldi

¹Naval Hospital Marcílio Dias (Hospital Naval Marcílio Dias - HNMD), Rio de Janeiro (RJ), Brazil. biaguaraldi@hotmail.com

Anais Brasileiros De Dermatologia

|March 30, 2013

Summary

Progressive symmetrical erythrokeratodermia, a rare genetic skin disorder, presents as distinct red, thickened plaques. This case highlights a late diagnosis and family history in a 55-year-old patient.

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Last Updated: May 12, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

Dermatology
Genetics
Rare Diseases

Background:

Progressive symmetrical erythrokeratodermia (PSE) is a rare autosomal dominant genodermatosis.
First described by Darier in 1911, PSE is characterized by variable penetrance.

Observation:

A 55-year-old patient presented with erythematous and keratotic plaques.
Lesions were symmetrically distributed on the hands, wrists, groin, and feet.

Findings:

The case illustrates a rare instance of late diagnosis for PSE.
Clinical presentation showed significant lesion profusion and evidence of familial involvement.

Implications:

This case underscores the importance of recognizing atypical presentations of PSE.
Further research into genetic factors and clinical variability of PSE is warranted.