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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

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REMUS100 AUV with an integrated microfluidic system for explosives detection.

André A Adams¹, Paul T Charles, Scott P Veitch

¹US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering (Code 6900), 4555 Overlook Ave. SW, Washington, DC 20375, USA. andre.adams@nrl.navy.mil

Analytical and Bioanalytical Chemistry

|March 30, 2013

Summary

This study demonstrates novel microfluidic immunosensors for real-time detection of trace explosives in seawater. The high-throughput system successfully quantified explosives on an autonomous underwater vehicle, enhancing marine safety.

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Area of Science:

Environmental Science
Analytical Chemistry
Sensor Technology

Background:

Real-time detection of trace explosives in marine environments is crucial for security.
Existing methods often lack the speed and on-site capability required for marine deployment.
Autonomous underwater vehicles offer a platform for in-situ environmental monitoring.

Purpose of the Study:

To demonstrate the effectiveness of novel high-throughput microfluidic immunosensors (HTMI) for detecting trace explosives in marine settings.
To assess the performance of HTMI systems during field trials on an autonomous underwater vehicle.
To evaluate the potential of HTMI for real-time, on-site quantitation of explosive materials.

Main Methods:

Field trials were conducted using a HYDROID REMUS100 autonomous underwater vehicle equipped with HTMI.
Displacement-based immunoassays were performed onboard the vehicle to detect nitroaromatic compounds.
Seawater was sampled continuously at a flow rate of 2 mL/min without pretreatment.

Main Results:

The HTMI system successfully detected and quantified trace levels of trinitrotoluene (20-175 ppb) in seawater.
No device failures due to clogging or leaks were observed during 2-hour deployments.
A 20-fold increase in flow rate significantly reduced assay lag and analysis times.

Conclusions:

Novel HTMI are suitable for real-time, on-site detection of trace explosives in marine environments.
The developed system demonstrates robust performance and reliability on autonomous underwater vehicles.
This technology can enhance security for civilians, waterways, and military personnel.