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Impact of preprocedural high-sensitivity C-reactive protein on contrast-induced nephropathy in patients undergoing

Zhang Jian-Wei1, Zhou Yu-Jie, Cao Shu-Jun

  • 11Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing, China.

Angiology
|March 30, 2013
PubMed

Insights

Pre-procedure high-sensitivity C-reactive protein (hsCRP) levels predict contrast-induced nephropathy (CIN) risk in ST-segment elevation myocardial infarction (STEMI) patients. Higher hsCRP levels correlate with increased CIN incidence after primary percutaneous coronary intervention (p-PCI).

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Contrast-induced nephropathy (CIN) is a complication following periprocedural myocardial infarction.
  • High-sensitivity C-reactive protein (hsCRP) is an inflammatory marker associated with cardiovascular events.

Purpose of the Study:

  • To evaluate the association between preprocedural hsCRP levels and CIN incidence in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI).

Main Methods:

  • Retrospective analysis of 1452 STEMI patients undergoing p-PCI.
  • Patients were stratified into hsCRP quartiles.
  • CIN incidence and inhospital outcomes were compared across quartiles.

Main Results:

  • Overall CIN incidence was 14.6% (212 patients).
  • CIN incidence increased significantly with higher hsCRP quartiles (Q1: 7.44% to Q4: 21.49%; P < .001).
  • Adjusted analysis identified hsCRP >6.50 mg/L as a significant predictor of CIN.

Conclusions:

  • Preprocedural hsCRP is a significant independent predictor of CIN in STEMI patients undergoing p-PCI.
  • Elevated hsCRP levels are associated with increased risk of CIN and inhospital complications.

Keywords:
ST-segment elevation myocardial infarctioncontrast-induced nephropathyhigh-sensitivity C-reactive proteinprimary percutaneous coronary intervention

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