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Published on: March 5, 2022
Insulin-like growth factor 2 and insulin-like growth factor 2 receptor gene polymorphisms in idiopathic male
Nina Pereza1, Sasa Ostojić, Miljenko Kapović
1Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. nina.pereza@xnet.hr
Objective:
To test the association between insulinlike growth factor 2 (IGF2) ApaI and IGF2 receptor (IGF2R) Gly1619Arg gene polymorphisms and idiopathic male infertility.
Study Design:
Polymerase chain reaction and restriction fragment length polymorphism methods were performed to detect the IGF2 ApaI and IGF2R Gly1619Arg genotypes in 98 Croatian men with idiopathic infertility and 113 fertile men.
Results:
There were no significant differences between patients and controls according to genotype (chi2(IGF2) = 3.46, p = 0.177; chi2(IGF2R) = 1.12, p= 0.571, respectively) and allele frequencies (chi2(IGF2) = 3.23, p = 0.072; chi2(IGF2R) = 0.99, p = 0.319, respectively). Odds ratios for recessive, dominant and codominant models and association testing with each genotype combination revealed no difference between infertile men and controls.
Conclusion:
In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility.
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