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Ischemic cerebrovascular disease and calcified intracranial vertebrobasilar artery: A case-control study by using

Orasa Chawalparit1, Surapong Chareewit

  • 1Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. oak_art@yahoo.com

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|April 2, 2013
PubMed

Insights

Vertebrobasilar (VB) artery calcification showed no significant link to posterior circulation ischemic stroke in the cerebellum and brainstem. However, VB artery calcification was associated with infarction in the end territories supplied by the vertebrobasilar system.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Intracranial vertebrobasilar artery calcification is a potential risk factor for ischemic cerebrovascular disease.
  • Posterior circulation strokes, affecting the cerebellum and brainstem, can result from vertebrobasilar system compromise.

Purpose of the Study:

  • To investigate the association between intracranial vertebrobasilar artery calcification and ischemic cerebrovascular disease in the posterior circulation.
  • To determine if VB artery calcification predicts posterior fossa infarction.

Main Methods:

  • A retrospective, case-control study involving 198 patients (104 with posterior fossa infarction, 94 controls).
  • Cranial CT was used to assess the presence, circumference, and thickness of calcification in the intracranial vertebral and basilar arteries.
  • Statistical analysis was performed to determine the association between VB calcification and posterior fossa infarction.

Main Results:

  • No statistically significant relationship was found between VB artery calcification and posterior fossa infarction overall (p = 0.08).
  • Subgroup analysis revealed a significant association between VB calcification and infarction in areas supplied by the VB system, including the occipital lobe and thalamus (p = 0.02).
  • No correlation was observed between the degree of calcification and the infarction area.

Conclusions:

  • Intracranial VB artery calcification is not significantly associated with ischemic infarction of the cerebellum and brainstem.
  • A significant relationship exists between VB artery calcification and infarction in the terminal vascular territories supplied by the VBA.
  • Further research may clarify the specific role of VB calcification in different posterior circulation stroke etiologies.
Abstract

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