Combining field therapies for actinic keratoses: novel approaches that intensify photodynamic therapy

Actinic keratosis (AK) is a common dermatologic condition resulting from long-term sun exposure. It is considered a precancerous lesion that may convert into a squamous cell carcinoma, which highlights the importance of prompt identification, early treatment and eradication of AK, and recurrence monitoring. Currently, there are many treatments available for widespread AKs that include a combination of local lesion destruction along with stimulation of an individual's immune response. Preliminary data from combination therapy studies demonstrate that these may offer improved efficacy, tolerability, and long-term results compared with monotherapy. The authors investigate combination systems aimed at intensifying photodynamic therapy for the treatment of AKs as reported at the 8th World Congress of the International Academy of Cosmetic Dermatology in Cancun, Mexico, and include a comprehensive literature review. Further investigations and data collection are in progress in order to solidify these promising results.