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Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...

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Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
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Silver nanoparticles -- allies or adversaries?

Teresa Bartłomiejczyk1, Anna Lankoff, Marcin Kruszewski

  • 1Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.

Annals of Agricultural and Environmental Medicine : AAEM
|April 2, 2013
PubMed
Summary

Silver nanoparticles (AgNP) offer benefits but pose risks due to their cytotoxicity and genotoxicity. Further research is needed to understand AgNP

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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

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Area of Science:

  • Nanotechnology
  • Toxicology
  • Cell Biology

Background:

  • Nanoparticles (NP) possess unique properties, with silver nanoparticles (AgNP) widely used for their bactericidal effects.
  • AgNP applications span medicine, cosmetics, textiles, and electronics.
  • Potential public health and environmental risks associated with AgNP necessitate careful consideration.

Purpose of the Study:

  • To review and synthesize data on the biological effects of AgNP in mammalian cells in vitro.
  • To elucidate the mechanisms underlying AgNP's cellular uptake, excretion, localization, cytotoxicity, and genotoxicity.
  • To highlight the need for further molecular-level studies for safe AgNP application.

Main Methods:

  • In vitro studies on mammalian cells.
  • Review of existing data on AgNP biological effects.
  • Analysis of cellular uptake, excretion, and compartment localization.
  • Assessment of cytotoxicity and genotoxicity.

Main Results:

  • AgNP are cyto- and genotoxic, accumulating in the environment.
  • Their antibacterial properties can negatively impact agriculture and waste management.
  • AgNP induce oxidative stress, ROS generation, and DNA damage.
  • Cellular responses include inflammation, apoptosis, and necrosis.

Conclusions:

  • AgNP exhibit significant biological effects on mammalian cells, including cytotoxicity and genotoxicity.
  • Mechanisms involve oxidative stress induction and subsequent cellular damage.
  • Further detailed molecular-level investigations are crucial for ensuring the safe application of AgNP.