Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.8K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.8K
Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

3.5K
No description available
3.5K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancient DNA reveals pervasive directional selection across West Eurasia.

Nature·2026
Same author

Functional dissection of complex trait variants at single-nucleotide resolution.

Nature·2026
Same author

Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Rewriting regulatory DNA to dissect and reprogram gene expression.

Cell·2025
Same author

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes.

Science (New York, N.Y.)·2025
Same author

A standing platform for cancer drug development using ctDNA-based evidence of recurrence.

Nature reviews. Cancer·2024

Related Experiment Video

Updated: Feb 12, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Lessons from the cancer genome.

Levi A Garraway1, Eric S Lander

  • 1Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Cell
|April 2, 2013
PubMed
Summary

Cancer genome studies have identified numerous new cancer genes involved in various cellular processes. Further research is needed to complete the cancer mutational catalog and translate genomic discoveries into targeted therapies.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Recent years have seen an explosion in systematic cancer genome studies.
  • These studies have uncovered numerous novel cancer genes.
  • Many identified genes are involved in previously unrecognized cancer-related processes.

Purpose of the Study:

  • To summarize recent advancements in cancer genomics.
  • To highlight the diverse cellular processes affected by newly discovered cancer genes.
  • To underscore the ongoing challenges and future directions in the field.

Main Methods:

  • Systematic analysis of cancer genomes.
  • Identification and characterization of cancer-associated genes.
  • Investigation of gene functions in cellular signaling, epigenomics, RNA splicing, protein homeostasis, metabolism, and lineage maturation.

More Related Videos

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K

Main Results:

  • Discovery of a multitude of new cancer genes.
  • Identification of novel cancer targets in cell signaling, chromatin and epigenomic regulation, RNA splicing, protein homeostasis, metabolism, and lineage maturation.
  • Recognition that cancer genomics is still an emerging field.

Conclusions:

  • Cancer genomics has rapidly advanced, revealing new gene targets.
  • Significant work remains to complete the mutational catalog and understand gene functions.
  • Future efforts should focus on linking genomic alterations to pathways and vulnerabilities to guide cancer therapy development.