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Updated: May 12, 2026
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Interplay between the cancer genome and epigenome
1USC Epigenome Center, University of Southern California, Room G511B, 1450 Biggy Street, Los Angeles, CA 90089-9061, USA.
Cell
|April 2, 2013
Summary
Cancer involves accumulated genetic and epigenetic changes that give cells a growth advantage. This study explores how genome and epigenome alterations cooperate to drive cancer development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cancer develops from cumulative disruptions in cellular growth control.
- Heritable changes conferring clonal advantage are selected for during cancer progression.
- These traits can be acquired through genetic or epigenetic alterations.
Purpose of the Study:
- To explore the interplay between genome and epigenome alterations in cancer.
- To understand how these changes cooperate to promote oncogenic transformation.
Main Methods:
- Review and synthesis of existing research on cancer genetics and epigenetics.
- Analysis of mechanisms by which genetic and epigenetic alterations influence each other.
Main Results:
- Alterations in the genome and epigenome are not independent but cooperate in cancer development.
- Disruption of epigenomic control is a common feature in malignancy.
- Epigenomic disruption acts as an enabling characteristic for cancer cells.
Conclusions:
- The interaction between genetic and epigenetic changes is crucial for oncogenic transformation.
- Epigenetic dysregulation is a fundamental aspect of cancer, comparable to genome instability.
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