Related Experiment Video
Updated: May 12, 2026

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
Published on: January 17, 2011
What is the best airway clearance technique in cystic fibrosis?
1Portex Department, 6th Floor, Cardiac Wing, Institute of Child Health, University College London, 30 Guilford Street, London WCIN 1EH. e.main@ucl.ac.uk
Abstract:
The global development of airway clearance techniques (ACTs) for cystic fibrosis (CF) and corresponding research spans over four decades. Five Cochrane reviews synthesising the evidence from a plethora of early short and medium term studies have not uncovered any superior method. Four recent long term RCT studies exposed fundamental shortcomings in the standard RCT trial design and the insensitivity of FEV1 in physiotherapy studies. Strong patient preference, lack of blinding and the requirement for effortful and demanding participation over long intervals will continue to derail efforts to find the best ACT for CF, unless they are addressed in future clinical trials.
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Cardiopulmonary Resuscitation II: ACLS Airway Management
Chest Physiotherapy
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...

