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Updated: May 12, 2026
10:29
Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
Published on: August 29, 2012
Ocular graft-versus-host disease: a review
Hasanain Shikari1, Joseph H Antin, Reza Dana
1Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
Survey of Ophthalmology
|April 2, 2013
Summary
Graft-versus-host disease (GVHD) causes significant complications after stem cell transplants. Ocular GVHD is the most frequent cause of long-term patient morbidity and requires focused treatment strategies.
Area of Science:
- Hematology
- Immunology
- Ophthalmology
Background:
- Graft-versus-host disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation (HSCT).
- Systemic GVHD affects the skin, gastrointestinal tract, and liver, but ocular manifestations are a primary source of chronic morbidity.
- Understanding GVHD is crucial for improving patient outcomes post-HSCT.
Purpose of the Study:
- To review the etiology, pathophysiology, clinical manifestations, and treatment of acute and chronic systemic GVHD.
- To emphasize the significant impact and management of ocular GVHD.
Main Methods:
- Literature review of acute and chronic GVHD.
- Focus on ocular surface disease in the context of systemic GVHD.
- Synthesis of current knowledge on GVHD mechanisms and treatments.
Main Results:
- Ocular surface disease is the most common cause of long-term morbidity in GVHD patients.
- Systemic GVHD symptoms can overshadow ocular manifestations.
- Effective management strategies for ocular GVHD are critical.
Conclusions:
- GVHD poses significant challenges after HSCT, with ocular complications being particularly prevalent for long-term morbidity.
- A comprehensive understanding of GVHD, especially ocular involvement, is essential for optimizing patient care and outcomes.
- Further research into targeted treatments for ocular GVHD is warranted.
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