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Updated: May 12, 2026
Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Apparent diffusion coefficient and diffusion-weighted signal intensity of the interpeduncle region of the midbrain in
Deting Ma1, Cheng Liu, Qingkui Kong
1Department of Radiology, Shandong Medical Imaging Research Institute, Shandong University, Jinan, 250021, PR China. medimage@163.com
Objective:
The diffusion-weighted signal intensity (SI) of the interpeduncle region (IPR) of the midbrain has not been fully understood. This study was to evaluate the apparent diffusion coefficient (ADC) and SI of the IPR on axial diffusion-weighted imaging (DWI).
Methods:
Axial brain DWI (4-mm slice thickness, no gap) was performed in 145 healthy subjects at 1.5T MR scanner. Correlations between the contrast-to-noise ratio (CNR) and ADC value in the IPR and age, gender were statistically analyzed.
Results:
The CNR was significantly higher in the IPR than in the periaqueductal gray (PAG) (P<.001). The CNR of the IPR positively correlated with age (P=.032) but not with gender (P=.091). The ADC value was significantly lower in the IPR than in the PAG (P<.001). The ADC value of the IPR did not correlate with age (P=.522) or gender (P=.217). There was no correlation between the CNR and ADC value of the IPR (P=.622).
Conclusions:
The IPR usually shows high SI on DWI in healthy subjects, especially in older adults. DWI combined with the ADC maps would help to evaluate signal characteristics of the IPR.
