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Updated: Aug 6, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
The lens after renal transplantation
G A Shun-Shin1, P Ratcliffe, A J Bron
1Clinical Cataract Research Unit, Nuffield Laboratory of Ophthalmology, University of Oxford.
The British Journal of Ophthalmology
|May 1, 1990
Summary
Renal transplant patients may develop posterior subcapsular cataracts (PSC). These cataracts, termed "recovering" PSC, appear linked to the peritransplant period, not ongoing immunosuppressive therapy.
Area of Science:
- Ophthalmology
- Nephrology
- Transplantation
Background:
- Posterior subcapsular cataract (PSC) is a known complication in some patient populations.
- Renal transplant recipients often require long-term immunosuppression, potentially increasing cataract risk.
Purpose of the Study:
- To investigate the characteristics and prevalence of posterior subcapsular cataracts (PSC) in non-diabetic renal transplant patients.
- To differentiate PSC in renal transplant recipients from age-related PSC.
Main Methods:
- A masked observer examined 55 non-diabetic renal transplant patients (mean age 41, mean time post-transplant 4.4 years).
- Lens axial thickness was measured and compared to a control group of 99 patients with clear lenses.
- Ocular examinations focused on the location and characteristics of any observed opacities.
Main Results:
- Fourteen (25%) patients developed PSC.
- Renal transplant patients with PSC had significantly thicker lenses compared to controls.
- PSC in this cohort was distinguished by superficial cortical opacity, depth proportional to time post-transplant, and a normal anterior clear zone.
Conclusions:
- A unique form of PSC, termed 'recovering' PSC, is identified in renal transplant recipients.
- The cataractogenic insult likely occurs during the peritransplant period.
- Maintenance immunosuppressive therapy or steroids are probably not the primary cause of this type of cataract.
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