Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world evidence for passive video-based cardiac monitoring from smartphones used by patients with a history of AF.

Journal of electrocardiology·2025
Same author

Measurements of pulse rate using facial video cameras from smart devices in patients diagnosed with atrial fibrillation.

Journal of electrocardiology·2023
Same author

Study of "ALS reversals": LifeTime environmental exposures (StARLiTE).

Amyotrophic lateral sclerosis & frontotemporal degeneration·2022
Same author

A patient-centred web-based adverse drug reaction reporting system identifies not yet labelled potential safety issues.

European journal of clinical pharmacology·2021
Same author

The diagnostic value of the neurological examination in coma of unknown etiology.

Journal of neurology·2021
Same author

[Hepatitis C in a psychiatric setting: A forgotten reservoir?]

L'Encephale·2020
Same journal

Measuring antidepressant side effects in military personnel - Clinical validation of the French version of the UKU-SERS-Pat Scale: A comparative study of patient and clinician ratings.

L'Encephale·2026
Same journal

[Empowerment in addictology].

L'Encephale·2026
Same journal

Evaluation of the links between smoking and conspiracy mentality.

L'Encephale·2026
Same journal

Use of a relevance assessment tool in therapeutic residential care: A real world study.

L'Encephale·2026
Same journal

Prevalence and characteristics of domestic violence in a sample of adult psychiatric outpatients: A cross-sectional study.

L'Encephale·2026
Same journal

From representations to practice: how professionals describe supporting parents with psychiatric or somatic illness or disability.

L'Encephale·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

[Atypical depression: Clinical perspectives].

M Lutz1, A Morali, J-P Lang

  • 1Centre hospitalier d'Erstein, 13, route de Krafft, BP 30063, 67152 Erstein, France.

L'Encephale
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Atypical depression remains a valid diagnostic concept due to its unique features and treatment responses. Further research with newer antidepressants and neuroimaging is recommended to solidify its clinical utility and connection to bipolar disorder.

Keywords:
Atypical depressionBipolar disorderDSM-IVDSM-VDépression atypiqueTroubles bipolaires

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Related Experiment Videos

Last Updated: May 12, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Context:

  • The diagnostic validity of atypical depression has been debated, particularly with the advent of newer pharmacological treatments.
  • Understanding atypical depression is crucial for accurate diagnosis and effective management of mood disorders.
  • The relationship between atypical depression and bipolar disorder requires further elucidation.

Purpose:

  • To examine the continued validity of atypical depression as a diagnostic subtype in light of recent antidepressant research.
  • To review the historical origins and evolving definitions of atypical depression.
  • To explore the potential link between atypical depression and bipolar disorder.

Summary:

  • A review of publications indicates that atypical depression is a valid syndrome, particularly in relation to early antidepressant trials.
  • While current evidence supports its validity, further studies using the latest antidepressants and atypical antipsychotics are necessary.
  • A strong association between atypical depression and bipolar disorders is suggested, warranting additional investigation.

Impact:

  • Atypical depression remains a clinically useful concept due to its distinct presentation, course, and treatment profile.
  • Recognizing atypical depression may aid in the diagnosis of bipolar disorders and prompt evaluation of suicidal risk and addiction.
  • The findings support the inclusion of atypical depression in future diagnostic manuals like the DSM-V.